Do you have a Master’s degree and are looking for fully funded PhD opportunities? Netherlands Cancer Institute, Netherlands is now accepting applications for several funded PhD programs across a range of research areas.
1. Fully Funded PhD in Computational Cancer Biology/Immunology
Summary of Funded PhD Program
The Netherlands Cancer Institute is spearheading neo-adjuvant immunotherapy in multiple tumor types, with spectacular results, leading to a significant increase in the survival of patients. Our main area of research is in the pre-operative setting, which allows for extensive collection of patient materials pre- and on-treatment at different timepoints. These paired tumor tissues and blood provide us with the unique opportunity to study the effect of immunotherapy combination treatments on the cancer tumor microenvironment, providing novel insights to improve patient selection and develop new treatment strategies. Commonly used assays include whole exome whole transcriptome sequencing, imaging mass cytometry of the tumor microenvironment and single-cell sequencing.
Application Deadline: November 30 2024
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2. Fully Funded PhD in Chemosensing
Summary of Funded PhD Program
Within the research divisions Molecular Pathology and Tumor Biology & Immunology, we investigate how the hormonal cycle of women affects immune cells, cancer cells, and sensitivity to therapies. Under the supervision of Prof. Jacco van Rheenen, Prof. Sabine Linn, and Prof. Marleen Kok, and in collaboration with national and international partners, we have shown in a mouse study that the hormonal cycle significantly influences the behavior and sensitivity of breast cancer cells to treatments, partly through continuous changes in the immune system. We have validated these findings in a small group of patients.
Application Deadline: Open until filled
3. 02 Fully Funded PhD in transcription factor binding at the single-molecule level
Summary of Funded PhD Program
Precise regulation of transcription is essential to ensure that the correct genes are expressed in the correct tissue at the correct time. At the basis of gene regulation are gene-specific transcription factors (TFs), which are essential to activate or repress transcription of their target genes in specific tissues. Previous work from our and other labs (Pomp, Mol Cell, 2024) have shown that many TFs bind to DNA cooperatively, but how this cooperativity is established is largely unclear. In the first project (Tineke Lenstra group, NKI), we aim to uncover how transcription factor binding dynamics and cooperativity are regulated by nucleosomes, self-interactions, and DNA shape, and how these mechanisms regulate single-cell transcription dynamics.
Application Deadline: Open until filled
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