Multiple postdoc positions are available in Ailong Ke’s Laboratory
Postdoc @Yale University posted 2 weeks agoJob Description
The Ke lab applies cutting-edge biochemical and biophysical tools to understand molecular mechanisms in RNA-guided processes, and to develop novel genome editing applications based on the mechanistic understanding. Research details can be found in our laboratory and departmental web sites. Representative publications include: Mol Cell. 2024;84(3):463-475; Science. 2022;377(6612):1278-1285; Science. 2022;376(6600):1476-1481; Nature. 2021;598(7881):515-520; Molecular Cell. 2019;74(5):936-950; Science. 2018;361(6397); Nature. 2017;550(7674):137-141; Cell. 2017;170(1):48-60; Nature. 2016;530(7591):499-503.
1) Structural biology or single molecule biophysics: Projects will push the ceiling of mechanistic biology through high-resolution structure determination or single molecule biochemistry. Ideal candidate should have strong background in nucleic acid biochemistry and biophysics. Experience in microbial engineering is considered a plus. The lab has routine access to Krios and FIB-milling instruments.
2) Genome editing: Projects involve developing novel genome editing tools and optimizing in vivo delivery approaches. Ideal candidate should have strong background in nucleic acid biochemistry, various deep sequencing techniques, and mammalian cell culture handling. Experience in mRNA synthesis and delivery or mouse work is considered a plus.
3) Protein and RNA engineering: Projects involves developing/improving novel genome editing tools using AI- or high throughput-based approaches. Ideal candidate should have strong background in AI, directed evolution, or deep mutational scanning.
Qualifications:
Candidates should have published at least one first-author paper in a reputable journal and hold a Ph.D. or equivalent degree before arrival. Please send your CV, list of publications, and three recommendation letters to ailong.ke@yale.edu for consideration.
