Do you have a Master’s degree and are looking for fully funded PhD opportunities? University of Dundee, Dundee, Scotland is now accepting applications for several funded PhD programs across a range of research areas.
1. Fully Funded PhD in Destroying cancer-causing proteins
Summary of Funded PhD Program
This PhD project aims to understand the molecular mechanisms by which FAM83F and FAM83G activate Wnt signalling and explore if targeted degradation of FAM83F and/or FAM83G inhibits Wnt-dependent proliferation of colorectal and other cancers. The project will employ a wide range of multi-disciplinary cutting-edge technologies, such as CRISPR/Cas9 genome editing, mass-spectrometry, DEL screens to identify ligands for FAM83F/FAM83G, and development and application of small molecule degraders, including PROTACs and molecular glues, of FAM83F-CK1-alpha and FAM83G-CK1-alpha complexes.
Application Deadline: 31 October 2024
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2. Fully Funded PhD in Finding the eat-me signals
Summary of Funded PhD Program
A project is available to decipher the signals that lead to the specific autophagy of mitochondria (termed mitophagy), a process that has strong links to cancer and in particular Parkinson’s disease. Following up on recently published work, the project will utilise state-of-the-art microscopy, cell biology, protein biochemistry and mass spectrometry to identify phosphorylation and ubiquitylation events involved in capturing mitochondria for degradation. As well as gaining experience in a wide variety of techniques, you will be part of a dynamic and collaborative team intent on making new scientific discoveries and producing the next generation of world-class scientists.
Application Deadline: 31 October 2024
3. Fully Funded PhD in New technologies to monitor assembly of alternative forms of the proteasome
Summary of Funded PhD Program
The PhD project aims at engineering the proteasome to develop new technologies to monitor assembly of its alternative forms suitable for high-throughput screening. This will be instrumental in better understanding the function of alternative forms of the proteasomes and will help understand their involvement in diseases. The project will offer training opportunities in state-of-the-art technologies such as cell engineering (CRISPR-Cas9 gene editing of proteasome genes), molecular biology (proteasome and protein degradation assays), and high-resolution confocal microscopy (proteasome dynamics).
Application Deadline: 31 October 2024
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4. Fully Funded PhD in The antiviral roles of ISG15 modifications
Summary of Funded PhD Program
This project takes advantage of our expansive toolkit to study the ISG15 system. Students interested in gaining expertise in a wide variety of approaches are strongly encouraged to apply since the project merges several disciplines, including method development, state-of-the-art mass spectrometry, cell biology, structural biology, biophysics, and biochemistry (3-4). The student will have a unique opportunity to work at the bench alongside their supervisor and the opportunity to participate in several internal and external collaborations.
Application Deadline: 31 October 2024
5. Fully Funded PhD in Investigating the immune-epithelial interactions that drive intestinal inflammation
Summary of Funded PhD Program
The aim of this project is to investigate how specific signalling components in allows them to adapt to the intestinal microenvironment and mount appropriate responses to intestinal perturbations, including diet and microbial challenges. The discovery that PIM kinases uniquely regulate metabolic activation of IEL (2), and that T-cell receptor signalling in IEL is uniquely modified (3) , and that IEL have a unique metabolic signature (4), all suggest that changes in these molecular components are necessary for IEL to function. In this project, the student will learn to use state-of-the-art techniques including proteomics and phosphoproteomics, signalling studies to investigate the pathways regulating IEL responses, Ribo-Seq to rapidly identify changes in IEL, and in vivo models to address how perturbations in signalling pathways regulate intestinal homeostasis.
Application Deadline: 31 October 2024
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6. Fully Funded PhD in How do Dysregulated Signalling Pathways cause Intellectual Disability?
Summary of Funded PhD Program
This PhD project aims to map signalling pathways that are disrupted in intellectual disability, with the overarching goal of uncovering much-needed therapeutic opportunities in this area. The successful candidate will have the opportunity to utilise exciting new tools and reagents in the lab and expand on our recent progress in dissecting intellectual disability signalling networks. Potential approaches include (phospho)proteomic profiling mass-spectrometry, modelling human neural development using pluripotent stem cells, animal models of intellectual disability, cutting edge biochemistry, and structural analysis using Cryogenic Electron Microscopy (CryoEM).
Application Deadline: 31 October 2024
7. Fully Funded PhD in Molecular mechanisms underlying Parkinson’s disease
Summary of Funded PhD Program
This project will provide training expertise in the state-of-the-art biochemistry, molecular biology, cell signalling, mass spectrometry, data analysis, working in a collaborative environment as well as statistics, communication, written and oral presentation. This project would also offer opportunities to collaborate with pharmaceutical companies and clinician’s treating patients and evaluating LRRK2 inhibitors for the management of Parkinson’s disease.
Application Deadline: 31 October 2024
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8. Fully Funded PhD in Identifying therapeutically-targetable mechanisms of PIK3CA mutant-specific signal transfer
Summary of Funded PhD Program
The Madsen Lab is dedicated to a systems understanding of PI3K signalling plasticity, inspired by observations from human disorders such as cancer and PIK3CA-related overgrowth spectrum (PROS) 1,2. Over the last five years, with support from Wellcome funding, we uncovered previously unappreciated allele dose-dependent effects of PIK3CA mutations in human pluripotent stem cells and cancer 3–5. Recently, we also developed a versatile single-cell experimental framework for studies of quantitative, PI3K-dependent information transfer, demonstrating for the first time that the most frequent oncogenic PIK3CA mutation, PIK3CAH1047R, is not a simple ON switch of the pathway as commonly assumed.
Application Deadline: 31 October 2024
9. Fully Funded PhD in Understanding the physiological roles and pathological impacts of ER-Autophagy
Summary of Funded PhD Program
A PhD project is available to understand the roles of other novel ER-phagy players uncovered from our genome-wide CRISPR screen. This project will utilise state-of-the-art microscopy, protein biochemistry, fluorescence microscopy, and CRISPR-based genetic manipulations to explore the roles of various novel factors in ER-phagy regulation and how their dysregulation translates to pathology.
Application Deadline: 31 October 2024
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10. Fully Funded PhD in Decoding the mechanism and function of UFMylation in ER Quality Control
Summary of Funded PhD Program
The goal of this project is to define how ribosomes get UFMylated upon stalling and to investigate the mechanisms and function of ribosome UFMylation. This project will build on our recent unpublished work, and we are looking for curious and creative students to work at the frontier of an exciting new field. What makes this project especially exciting is its potential to reveal a fundamental pathway responsible for quality control and homeostasis at the ER, the disruption of which causes disease.
Application Deadline: 31 October 2024
11. Fully Funded PhD in Cleave to Modify: A new biological mechanism for protein regulation
Summary of Funded PhD Program
This project aims to identify novel substrateis and pathways regulated by the “cleave-to-modify” mechanism and link these discoveries to a cellular function. What makes this project especially exciting is its potential to reveal unprecedented fundamental pathway responsible for regulation of homeostasis, the disruption of which causes disease.
Application Deadline: 31 October 2024
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12. Fully Funded PhD in Deciphering novel ALS signalling pathways: Biomarker discovery and developing therapeutic strategies
Summary of Funded PhD Program
A PhD project is available to develop a knowledgebase of TDP-43 loss of function (LoF) mediated cryptic splicing, identification of cryptic peptides, development of ultra-sensitive assays for mechanistic understanding TDP-43 LoF biology. This studentship provides a great opportunity to learn and employ human iPSC derived motor neurons and glial cell models (2), protein biochemistry, transcriptomics, quantitative proteomic analysis using state-of-the-art Ultra-sensitive mass spectrometry (Orbitrap Astral and tims-TOF SCP mass spectrometers), Bioinformatics, Proteogenomics (3) and targeted PRM mass spectrometry assays (4).
Application Deadline: 31 October 2024
13. Fully Funded PhD in How do atypical E3 ligases facilitate their biology?
Summary of Funded PhD Program
A PhD project is available to join our multidisciplinary lab and work on RCR/RZ E3 ligases using a combination of biochemistry and cryoEM/crystallography. Alternatively, we are continuing to develop new chemical biology techniques and technologies and could offer a project in this area 6. Hence, applications from individuals with either a biology or chemistry background are encouraged to apply.
Application Deadline: 31 October 2024
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14. Fully Funded PhD in Discovery of novel mitochondrial and organelle mechanisms underlying Parkinson’s disease
Summary of Funded PhD Program
Parkinson’s disease (PD) is a movement disorder that is now the fastest growing neurological disorder in the world. Despite much research the disease is incurable and there are no treatments that can slow the disease down. The discovery of genetic mutations in rare familial forms has transformed our understanding of the origins of PD but the function of these genes is poorly understood. Mutations in PTEN-induced kinase 1 (PINK1) cause autosomal recessive PD. PINK1 is unique amongst all protein kinases due to the presence of a mitochondrial targeting domain that localises it to mitochondria.
Application Deadline: 31 October 2024
15. Fully Funded PhD in Beyond Lysine: Exploring the Functional Consequences of Non-Canonical Ubiquitination in Health and Disease
Summary of Funded PhD Program
Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune responses. Traditionally, ubiquitin attaches to lysine residues via isopeptide bonds. However, recent advances have uncovered a novel form of ubiquitination – non-canonical ubiquitination – where ubiquitin binds to serine, threonine, and other hydroxyl-containing biomolecules through ester bonds. This dynamic and less stable modification challenges established paradigms and opens up new possibilities for interactions with other PTMs, such as phosphorylation and glycosylation, which could have far-reaching consequences on cell biology.
Application Deadline: 31 October 2024
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16. Fully Funded PhD in Pharmacogenetic and proteomic characterisation of response to Dipeptidyl peptidase-1 inhibitors: precision medicine for a novel class of anti-inflammatory drugs
Summary of Funded PhD Program
This project will combine a clinical translational study, investigating the proteome and transcriptome of neutrophils from different patient populations, and analysis of unique datasets (large population genetic datasets) and data taken from clinical trials of DPP1 inhibitors to investigate differences between patient groups in the neutrophil proteome, neutrophil functional responses, the genetics of DPP1 and its target proteases and how this translates into different responses to DPP1 inhibitors. Full training will be provided in bioinformatic and wet lab techniques.
Application Deadline: 1 November 2024
17. Fully Funded PhD in Impact of the alarmin Il-33 on neutrophilic inflammation in chronic lung disease
Summary of Funded PhD Program
In this project we will investigate the in-vitro and in-vivo impact of IL-33 blockade on neutrophilic inflammation. The project will involve culture of primary neutrophils and epithelial cells from people with chronic lung disease and healthy controls, cell stimulation with IL-33 followed by targeted assays and proteomics, and analysis of biological samples obtained from clinical trials in which patients are receiving anti-IL33 monoclonal antibodies. In addition to tissue culture, key laboratory techniques will include primary cell isolation, flow cytometry, immunohistochemistry and fluorescence microscopy, ELISA and functional assays.
Application Deadline: 1 November 2024
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18. Fully Funded PhD in How do bacteria adapt survive in the lungs of patients with chronic lung infections like bronchiectasis?
Summary of Funded PhD Program
In this project we will investigate the molecular mechanisms by which H. influenzae or P. aeruginosa adapt and survive in the lungs of patients with bronchiectasis. The project will involve culturing clinical isolates and lab strains in vitro in the presence of other bacteria and immune products in a range of microbiological assays to understand variation between bacterial responses, both functionally and at the transcriptional level. Whole genome sequencing will then be used to see genetic difference between strains and detect contributing virulence factors. Any potential virulence factors will then be validated in laboratory strains. Primary neutrophils, and immune cells from patients, will be used to see how virulence factors influence immune responses.
Application Deadline: 1 November 2024
19. Fully Funded PhD in Improving the Reliability and Economy of Anchors for Floating Offshore Wind Energy
Summary of Funded PhD Program
This research aims to optimize the effectiveness of site investigation for the geotechnical design of FOWT anchors, resulting in a significant reduction in cost. This will be done by developing a reliability-based risk assessment framework. The uncertainties arising from the site characterisation process and anchor capacity prediction models will be evaluated, respectively. Building on these, a comprehensive reliability-based risk analysis model will be developed for FOWT anchors.
Application Deadline: 31 October 2024
