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06 PhD Programs – Fully Funded at Heidelberg Biosciences International Graduate School, Germany

Do you have a Master’s degree and are looking for fully funded PhD opportunities? Heidelberg Biosciences International Graduate School, Germany is now accepting applications for several funded PhD programs across a range of research areas.

1. Fully Funded PhD in Generative genomic sequence-to-function models to design cell type specific regulatory nucleotide sequences

Summary of Funded PhD Program

The cis-regulatory code governs when, where, and how much of gene products are created in cells, enabling the formation of various cell types from a single genome. Genomic sequence-to-function models can learn the cis-regulatory language from a large set of genome-wide measurements. Combining these deep sequence-to-function models with generative processes enables us to exploit these model’s knowledge to generate new synthetic sequences with specific regulatory functions. However, many different challenges remain in this process, such as model uncertainty outside of training distributions, lacking sequence diversity and variation. A big issue for algorithm development is the lack of experimental feedback. After training on an original data set, subsequent rounds to assess the designed sequences are often inaccessible to computational labs.

Application Deadline: 10 Nov 2024

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2. Fully Funded PhD in Multi-modal Deep Neural Networks to understand the cis-regulatory code at single-cell resolution

Summary of Funded PhD Program

The cis-regulatory code governs when, where, and how much of gene products are created in cells, enabling the formation of various cell types from a single genome. Variants disrupting this code can lead to genetic diseases. Experimentally measuring all cis-regulatory sequence variations is nearly impossible. However, deep sequence-to-function models can learn the relationship between genomic sequences and their regulatory function from massive collections of genome-wide datasets. In this process, they gain knowledge about the regulatory sequence grammar of our cells which can be used to predict the effects of unseen regulatory sequences. However, current state-of-the-art models have limitations, particularly in understanding complex sequence grammar arising from the complex multi-layered regulatory processes or the interplay of distal sequence elements.

Application Deadline: 10 Nov 2024

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3. Fully Funded PhD in Impact of vascular cells on cardiac remodelling and heart failure

Summary of Funded PhD Program

The main focus of our lab is the study of the molecular mechanisms of heart failure using different mouse models of the disease. In the planned project, we aim to investigate the role of endothelial cells on myocardial remodelling and fibrosis in response to cardiac overload. The planned project will use a wide spectrum of technologies, including genetics, imaging, biochemistry, molecular biology, cell culture, organoid and experimental animal work, as well as bulk and single cell NGS approaches to study the dynamics of endothelial-cardiomyocyte crosstalk in myocardial disease.

Application Deadline: 30 Nov 2024

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4. Fully Funded PhD in Structure function analysis of gamma-tubulin complexes

Summary of Funded PhD Program

Gamma-tubulin complexes mediate the regulated formation of microtubules by acting as structural templates during the microtubule nucleation reaction. Understanding the structure and conformational plasticity of gamma-tubulin complexes is key to elucidating the molecular mechanisms underlying this central cellular process. The central objective of this project will be to determine structures of gamma-tubulin complexes in different functional states using state-of-the-art cryo-electron microscopy and tomography.

Application Deadline: 30 Nov 2024

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5. Fully Funded PhD in Novel assays for cuticular penetration and increased understanding of pharmacokinetics for insecticide use in malaria control

Summary of Funded PhD Program

We are looking to recruit a PhD student for a Gates Foundation funded project determining the pharmacokinetic properties necessary for insecticide uptake in the major malaria vector Anopheles gambiae sl. The appointee will join the Parasitology Unit in the Centre for Infectious Diseases, Heidelberg and be affiliated with Prof Carsten Hopf at the Center for Mass Spectrometry and Optical Spectroscopy, Mannheim. We will also work closely with other partners as part of a consortia for novel insecticide discovery, specifically with Dr David Hong, University of Liverpool, UK.

Application Deadline: 10 Dec 2024

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6. Fully Funded PhD in Regulation of chamber-specific mammalian cardiomyocyte polyploidization

Summary of Funded PhD Program

Our recent findings showed that cardiomyocyte polyploidization is regulated in a chamber-specific manner. Transcriptomic analyzes further revealed interesting differences in the composition of non-myocytes (e.g., immune cells and endothelium) as well as the extracellular matrix between the left atrium, right atrium, and the ventricle in the postnatal mouse heart. Building on these and other findings, we are looking for a motivated PhD candidate to join our team at the European Center for Angioscience to investigate how intercellular interactions regulates chamber-specific cardiomyocyte polyploidization.

Application Deadline: 31 Dec 2024

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